WebMar 1, 2024 · Activation of p53 in response to stress largely occurs through protein stabilization, thereby enabling rapid (within a few hours) increase in total protein abundance and initiation of the p53... WebQuestion: Question 1 How does activated p53 initiate apoptosis It causes significant DNA damage. It breaks down cell structures and proteins. It inactivates DNA damage repair mechanisms It activates the transcription of BAX and represses the transcription of It represses the transcription of BAX and activates the transcription of 2
To die or not to die: how does p53 decide? Oncogene
WebOct 2, 2013 · The apoptotic program is hardwired into every single cell in our body. It is like a cyanide capsule, swiftly delivering death if the circumstances require cellular suicide. If a cell detects that... WebMay 16, 2011 · Our results support the notion that p53 is activated in a progressive manner. First, p53 is primarily modified ... But when triggered by proapoptotic p53 pulses, it may take several hours to initiate apoptosis after the decision; this is inefficient in killing irreparable cells. In the present work including the ATM-p53-Wip1 and p53-PTEN-Akt ... how many times should pee a day
IJMS Free Full-Text Apoptosis in Cellular Society: …
WebMar 28, 2024 · Coronaviruses (CoVs) are a diverse family of single-stranded positive-sense enveloped RNA viruses that can induce a range of issues, including the stress response of host cells, cell cycle changes, cell apoptosis, and host immune dysregulation and inflammation [].They can infect humans and various vertebrates, leading to severe public … WebThe role of p53 in apoptosis The dynamic and multiple functions of p53, together with its involvement in the most common non-infectious diseases, underscore the need to elucidate the complexity of the p53 regulatory networks. Pathological conditions such as cancer, neurodegeneration, ischemia, cholestasis, and atherosclerosis a … WebOne of the most important functions of p53 is its ability to induce apoptosis, while disruption of this route can promote tumor progression and chemo resistance. Besides its ability to promote apoptosis through transcription dependent mechanisms, p53 may also be able to activate apoptosis independent of transcriptional regulation. how many times should i work out