List of platinum based chemotherapy agents

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WebPlatinum-based agents are important drugs or drug candidates for cancer chemotherapy. Traditional platinum drugs including the globally approved cisplatin, carboplatin and … Web15 mrt. 2024 · Key Points. Question How many cancer therapies approved by the US Food and Drug Administration between 2016 and 2024 displaced standard-of-care therapies vs being added to existing therapies in the metastatic, adjuvant, and maintenance settings?. Findings In this cross-sectional study, between May 1, 2016, and May 31, 2024, there …

Oxaliplatin: Uses, Dosage, Side Effects, Warnings - Drugs.com

Web16 mrt. 2024 · We read with great interest the letter by Poggio et al.,1 updating their previous meta-analysis on the role of platinum compounds in neoadjuvant chemotherapy (NAC) of triple-negative breast cancer (TNBC).2 The current results indicate that adding a platinum agent significantly increases event-free survival (EFS) but not overall survival … greatest tennis rivalries of all time

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WebComparison of single agent versus combined chemotherapy in previously treated patients with advanced urothelial carcinoma: a meta-analysis Xiao-Jun Wu, Yi Zhi, Peng He, Xiao-Zhou Zhou, Ji Zheng, Zhi-Wen Chen, Zhan-Song Zhou Institute of Urinary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, People’s Republic of … Web7 feb. 2024 · Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for chemotherapeutic eradication of cancer. However, the side effects of platinum drugs, … Web8 apr. 2024 · Anti-tumor agent cisplatin has been known to treat . melanoma for the past 30 years; exerting its toxic e ects by forming . ... Concomitant platinum-based chemotherapy or cetuximab with radiotherapy . flipping weights

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Chemotherapy: Pt anticancer agents - Chemistry LibreTexts

WebPlatinum compounds (e.g., carboplatin, cisplatin, oxaliplatin) have been central to the practice of oncology for the last 40 years.30 Cisplatin and carboplatin covalently bind to DNA causing intrastrand and interstrand DNA adducts. WebIn this network meta-analysis, we found that patients who received a triple combination of platinum-based chemotherapy reported more hematological complications such as anemia and thrombocytopenia but provided relatively higher PFS and OS. In our study, all patients were sensitive to platinum-based chemotherapy during the first-line treatment. flipping websites hypixelWeb1 jul. 2001 · Cisplatin (Platinol) isone of the most active drugs in non-small-cell lung cancer (NSCLC), with asingle-agent response rate of approximately 20%. In many different preclinicalmodels, platinum is synergistic with other chemotherapy drugs and withradiation. The superiority of platinum-containing chemotherapy was suggested bya … flipping wedges template

"Web13 apr. 2024 · Eighty-nine percent of patients previously received androgen-signaling inhibitor(s), 68% had platinum-based chemotherapy, and 50% had prior taxane chemotherapy. The median duration of follow-up was 30.8 weeks (range, 1.9-86.9), and the median duration of treatment was 9 weeks (range, 0.7-63). " - List of platinum based chemotherapy agents

List of platinum based chemotherapy agents

Platinum-based drugs for cancer therapy and anti-tumor strategies

WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck … WebAlkylating agents are effective during every phase of the life cycle of a cancer cell, which means they are effective for treating a wide range of cancers. They are most effective for treating slow-growing cancers such as leukemia and solid tumors , but are also used in the treatment of breast, lung, ovarian, and prostate cancers; lymphomas, myelomas, and …

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Web• platinum-based chemotherapy regimens – containing a chemotherapy drug known as a “platinum agent” in combination with other chemotherapy drugs and; • non … Web1 aug. 2007 · Key developments include the elucidation of mechanisms of tumour resistance to these drugs, the introduction of new platinum-based agents (oxaliplatin, satraplatin and picoplatin), and clinical combination studies using platinum drugs with resistance modulators or new molecularly targeted drugs. The accidental discovery of the …

WebPlatinum-based anticancer drugs, such as cisplatin, are standard chemotherapeutic agents in ovarian cancer therapy. Citation 39 , Citation 40 This class of drugs can penetrate the nucleus of cancer cells and form adducts with genomic or mitochondrial DNA to block the production of DNA, mRNA, and proteins, arrest DNA replication, and activate several … WebThis listing includes accelerated approvals (AAs) for malignant hematology and oncology indications that have been subsequently withdrawn, and are therefore, no longer FDA …

Web21 sep. 2016 · Randomized phase II and III clinical trials comparing first-line palliative platinum-based chemotherapy with the same regimen without platinum or with platinum replaced by a nonplatinum agent were identified by electronic searches of Medline, Embase, and Cancerlit, and hand searches of relevant abstract books and reference lists. Web14 apr. 2024 · Among 485 patients treated with first-line platinum-based chemotherapy, the probability of initiating maintenance avelumab increased over time following approval . In the 22 months after FDA approval, 99 of 485 patients (20.4%) treated with first-line chemotherapy and 78 of 321 maintenance-eligible patients (24.3%) received …

WebIn the absence of identified therapeutic targets, chemotherapy is the main systemic treatment option for triple-negative breast cancer (TNBC). The achievement of a …

WebL01XA — Platinum compounds. Drugs. Drug. Drug Description. Cisplatin. A platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Nedaplatin. Used in the treatment of non-small cell lung cancer, small cell lung cancer, oesophygeal cancer, and head and neck cancers . Oxaliplatin. flipping wheelsWebPlatinum agents are used to treat lymphomas, sarcomas, breast, colorectal, germ cell, ovarian, lung, gastro-oesophageal and bladder cancers. Most retrospective data … greatest tenors in historyWebChemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the uncontrolled growth and proliferation of cancer cells. They are classified according to their mechanism of action and include. alkylating agents. , antimetabolites. , topoisomerase inhibitors. , antibiotics, mitotic inhibitors, and. flipping weights vs worm weightsWeb21 dec. 2024 · Platinum (Pt) agents, usually referring to carboplatin (Cb) and cisplatin (DDP), are cytotoxic DNA-damaging chemo-drugs widely used in various malignancies. Platinum can cause DNA strand... flipping wendyWeb3 sep. 2024 · CHEMOTHERAPY AGENTS. High doses possible with stem cell rescue have very high prevalence of hearing reduction. total dose > 200 mg/sq meter. While reportedly ototoxic, these medications are rarely encountered as a source of vestibular dysfunction. In other words, while they can cause tinnitus or hearing loss, generally there is little long … flipping western unionWebComparison of single agent versus combined chemotherapy in previously treated patients with advanced urothelial carcinoma: a meta-analysis Xiao-Jun Wu, Yi Zhi, Peng He, Xiao … greatest tenor saxophonistsWeb20 jul. 2024 · Platinum-based chemotherapy with cisplatin (the prototype of platinum agents) and its derivatives, carboplatin and oxaliplatin, is traditionally the first-line cytotoxic treatment of lung, colorectal, ovarian, breast, head/neck, bladder and testicular cancers [].An expected side effect of these widely administered platinum-containing regimens is … flipping wholesale phones